First Pass Effect

Many orally administered medications travel to the liver where they are altered to form metabolites. When this occurs, the original active ingredient (drug substance) is diminished and the level of drug entering general circulation is reduced. In many cases, by-passing this “first pass effect” is desirable, since the drug substance may be efficacious while the metabolites may be toxic or ineffective.

When ALT® is used to formulate certain lipophilic pharmaceutical dosage forms, the “first pass effect” may be reduced or even by-passed allowing the intact moiety to reach general circulation. Undesirable metabolites are eliminated and efficacy is enhanced. ALT therefore allows for a lowered dose of active ingredient to be substantially more efficacious and sometimes with fewer side effects.